Protein electrostatics: From computational and structural analysis to discovery of functional fingerprints and biotechnological design

Protein electrostatics: From computational and structural analysis to discovery of functional fingerprints and biotechnological design

Computing driven protein engineering aims to enable them to withstand an extended range of conditions and to mediate modified or novel functions. Therefore, it is very important for industrial biotechnology, biomedical and pay for new challenges in environmental science, such as biocatalysis for green chemistry and bioremediation.

To achieve this goal, it is important to clarify the molecular mechanisms underlying the stability of proteins and modulate their interactions. So far, much attention has been given to the packing of hydrophobic and polar interactions and the stability of the protein core.

Instead, the role of electrostatics and, in particular, surface interactions has received less attention. However, electrostatics plays an important role throughout the entire life cycle of proteins, because the initial folding steps to maturation, and is involved in the regulation of protein localization and interaction with cellular or other artificial molecule. Short and long-range electrostatic interactions, together with other forces, provide important guidance cues in the assembly of molecules and macromolecules.

We report here on a method for calculating electrostatic and for analysis of individual proteins or protein capable comparison sort by electrostatic similarity. Then, we give examples of electrostatic and fingerprint analysis in the evolution of the natural protein in the design and biotechnology, in areas as diverse as biocatalysis, antibodies and nanobody engineering, drug design and delivery, molecular virology, nanotechnology and regenerative medicine.
Biomimetic has emerged as a multi-disciplinary knowledge in several subjects biomedicine in recent decades, including biomaterials and dentistry.

In restorative dentistry, biomimetic approach has been applied to a variety of applications, such as restoring defective teeth using bioinspired peptides to achieve remineralization, bioactive and biomimetic biomaterials, and tissue engineering for regeneration. Advances in modern adhesive restorative materials, understanding the biomaterial-tissue interaction at the nano and micro further improved restorative material properties (such as color, morphology, and strength) to mimic natural teeth.

 Protein electrostatics: From computational and structural analysis to discovery of functional fingerprints and biotechnological design
Protein electrostatics: From computational and structural analysis to discovery of functional fingerprints and biotechnological design

Evaluating the spectral overlap with the cooling rate in UCP luminescence energy transfer system

The use of organic fluorophores based on well-established as a key tool in the biological sciences, with many biological-sensing method takes advantage of Forster Resonance Energy Transfer (FRET) between fluorescent organic dyes based on the following different one photon excitation.

However, work by absorbing UV-visible dyes as fluorescent tags and markers typically suffer from several drawbacks including relatively high energy excitation wavelengths, and autofluorescence competitive photobleaching, which often limit their effectiveness and longevity both in vitro and in vivo.

Human Myeloma IgM

GWB-9E845B 2 mg Ask for price

IgG1 LAMBDA MYELOMA

GWB-1F43F7 1 mg Ask for price

Human Myeloma IgM Fc5u

GWB-785456 1 mg Ask for price

Human IgE Myeloma, Kappa

31-1010 100 ug
EUR 460
Description: Human IgE Myeloma, Kappa Protein

Human IgE Myeloma, Lambda

31R-AI032 200 ug
EUR 2500
Description: Purified Human IgE Myeloma, Lambda

Human Myeloma IgA2 kappa

GWB-50D1F7 1 mg Ask for price

Human Myeloma IgA1 kappa

GWB-81CAAB 5 mg Ask for price

Human Myeloma IgE Protein

abx061000-100ug 100 ug
EUR 1387.2

Human Myeloma IgM Protein

abx061005-5mg 5 mg
EUR 393.6

Human Myeloma IgM Protein

abx061006-2mg 2 mg
EUR 644.4

Human IgG1, Myeloma Plasma

20007-G1-1 1 mg
EUR 242.4

Human IgG2, Myeloma Plasma

20007-G2-1 1 mg
EUR 242.4

Human IgG3, Myeloma Plasma

20007-G3-1 1 mg
EUR 489.6

Human IgG4, Myeloma Plasma

20007-G4-500 500 ug
EUR 270

Human Myeloma IgA1 Lambda

GWB-2FBFF6 5 mg Ask for price

Human Myeloma IgE Protein

abx061000-100g 100 µg Ask for price

Human Myeloma IgE Protein

abx061000-10g 10 µg
EUR 1362.5

Human Myeloma IgE Protein

abx061000-50g 50 µg Ask for price

Leukemia - Multiple Myeloma Exosome

P141-MM - Ask for price

Myeloma Overexpressed (MYEOV) Antibody

20-abx113918
  • Ask for price
  • Ask for price
  • 150 ul
  • 50 ul

Myeloma Overexpressed (MYEOV) Antibody

abx235466-100ug 100 ug
EUR 661.2

Myeloma Overexpressed (MYEOV) Antibody

abx113918-100l 100 µl
EUR 612.5

Myeloma Overexpressed (MYEOV) Antibody

abx235466-100g 100 µg
EUR 350

Myeloma Overexpressed (MYEOV) Antibody

abx375599-96tests 96 tests
EUR 337.5

HUMAN, IGM (MYELOMA), HRP, 1 MG

9403724 1MG
EUR 258.89

Human IgG1 Fab fragment (myeloma)

20007-G1-Fab 100 ug
EUR 270

HUMAN, IGM (MYELOMA), FITC, 1 MG

9403723 1MG
EUR 288.17

Mouse Myeloma IgM k (TEPC 183)

GWB-32CF00 1 mg Ask for price

Human Myeloma IgA2 kappa Protein

abx060999-1mg 1 mg
EUR 427.2

Human Myeloma IgE lambda Protein

abx061003-1mg 1 mg
EUR 4869.6

Human Myeloma IgG1 kappa Protein

abx061004-1mg 1 mg
EUR 460.8

Human IgE Myeloma Lambda protein

31C-CP4013 100 ug
EUR 338
Description: Purified Human IgE Lambda protein

Mouse Myeloma IgG1 k (MOPC 21)

GWB-8F354F 1 mg Ask for price

Human Myeloma IgA1 lambda Protein

abx060998-5mg 5 mg
EUR 644.4

Immunoglobulin A2 (IgA2) Myeloma 95%

GWB-8EBF9E 1 mg Ask for price

Immunoglobulin A1 (IgA1) Myeloma 95%

GWB-A82DC0 1 mg Ask for price

Human Myeloma IgA1 lambda Protein

abx060998-100g 100 µg Ask for price

Human Myeloma IgA1 lambda Protein

abx060998-10g 10 µg
EUR 1325

Human Myeloma IgA1 lambda Protein

abx060998-50g 50 µg Ask for price

HUMAN, IGM (MYELOMA), BIOTIN, 1 MG

9403722 1MG
EUR 185.69

Leukemia - Multiple Myeloma Exosome RNA

P241-MM - Ask for price

Myeloma Overexpressed 2 (MYEOV2) Antibody

abx235467-100ug 100 ug
EUR 661.2

Myeloma Overexpressed 2 (MYEOV2) Antibody

abx235467-100g 100 µg
EUR 350

HUMAN, IGM (MYELOMA), UNCONJUGATED, 2 MG

9403720 1MG
EUR 244.25

Myeloma and bone marrow tissue array

T291e each
EUR 78
Description: Myeloma and bone marrow tissue array, 6 cases/ 24 cores (core size 1.5mm), replacing T291d

Human IgM, Myeloma Plasma (isotype control)

20007-2-M 1 mg
EUR 270

Human IgD, Myeloma Plasma (isotype control)

20007-8-50 50 ug
EUR 343.2

Human Myeloma Overexpressed (MYEOV) ELISA Kit

abx381630-96tests 96 tests
EUR 1093.2

Human IgA1 (myeloma) purified (isotype control)

20007-6-100 100 ug
EUR 196.8

Human IgA1 (myeloma) purified (isotype control)

20007-6-500 500 ug
EUR 562.8

Human IgA2 (myeloma) purified (isotype control)

20007-7-100 100 ug
EUR 196.8

Human IgA2 (myeloma) purified (isotype control)

20007-7-500 500 ug
EUR 562.8

Immunoglobulin M (IgM) Myeloma Whole PEROXIDASE

GWB-88CAF5 1 mg Ask for price

Goat Anti-Human IgM, Myeloma, Antisera (Bulk)

10217-GAS-BLK 1-10L, bulk Ask for price

GWB-81CAAB-5MG - Human Myeloma IgA1 kappa

GWB-81CAAB-5MG 5mg
EUR 485

Myeloma tissue array with bone marrow tissue

T291d each
EUR 78
Description: Myeloma tissue array with bone marrow tissue, 6 cases/24 cores, replacing T291c

GOAT ANTI HUMAN IGM, MYELOMA, ANTISERA, 100 ML

7455430-100ML 1ML
EUR 175.44

GOAT ANTI HUMAN IGM, MYELOMA, ANTISERA, 500 ML

7455430-500ML 1ML
EUR 821.11

GOAT ANTI HUMAN IGM, MYELOMA, ANTISERA, 1 LTR

7455430-1LTR 1LTR
EUR 1548.76

Human Myeloma Overexpressed 2 (COPS9) ELISA Kit

abx381631-96tests 96 tests
EUR 1093.2

*Human IgD from Myeloma Plasma Affinity Purified

IHUIGDMYAP100UG each
EUR 439
Description: *Human IgD from Myeloma Plasma Affinity Purified

*Human IgD from Myeloma Plasma Affinity Purified

IHUIGDMYAP500UG each
EUR 1144
Description: *Human IgD from Myeloma Plasma Affinity Purified

Human IgE from Myeloma Plasma Affinity Purified

IHUIGEMYAP100UG each
EUR 495
Description: Human IgE from Myeloma Plasma Affinity Purified

*Human IgM from Myeloma Plasma Affinity Purified

IHUIGMMYAP10MG each
EUR 740
Description: *Human IgM from Myeloma Plasma Affinity Purified

*Human IgM from Myeloma Plasma Affinity Purified

IHUIGMMYAP5MG each
EUR 439
Description: *Human IgM from Myeloma Plasma Affinity Purified

OPRA03561-1MG - IgM Kappa (kappa) myeloma protein

OPRA03561-1MG 1mg
EUR 249

OPRA03569-1MG - IgA Kappa (kappa) myeloma protein

OPRA03569-1MG 1mg
EUR 249

OPSA10725-1MG - Rat IgG1 LAMBDA MYELOMA Protein

OPSA10725-1MG 1mg
EUR 519

Human IgE (myeloma, Kappa), purified (isotype control)

20007-3-100 100 ug
EUR 489.6

Human IgE (myeloma, Kappa), purified (isotype control)

20007-3-1000 1000 ug
EUR 3567.6

*Human IgA1 from Myeloma Plasma Affinity Purified

IHUIGA1MYAP10MG each
EUR 664
Description: *Human IgA1 from Myeloma Plasma Affinity Purified

*Human IgA1 from Myeloma Plasma Affinity Purified

IHUIGA1MYAP5MG each
EUR 461
Description: *Human IgA1 from Myeloma Plasma Affinity Purified

*Human IgA2 from Myeloma Plasma Affinity Purified

IHUIGA2MYAP5MG each
EUR 532
Description: *Human IgA2 from Myeloma Plasma Affinity Purified

*Human IgG1 from Myeloma Plasma Affinity Purified

IHUIGG1MYAP10MG each
EUR 666
Description: *Human IgG1 from Myeloma Plasma Affinity Purified

*Human IgG1 from Myeloma Plasma Affinity Purified

IHUIGG1MYAP1MG each
EUR 136
Description: *Human IgG1 from Myeloma Plasma Affinity Purified

*Human IgG1 from Myeloma Plasma Affinity Purified

IHUIGG1MYAP5MG each
EUR 600
Description: *Human IgG1 from Myeloma Plasma Affinity Purified

Human IgG2 from Myeloma Plasma Affinity Purified

IHUIGG2MYAP5MG each
EUR 600
Description: Human IgG2 from Myeloma Plasma Affinity Purified

OPRA03544-1MG - IgG1 Kappa (kappa) myeloma protein

OPRA03544-1MG 1mg
EUR 249

Human IgM-HRP conjugate (myeloma, isotype control)

20007-2-MP 100 ug
EUR 196.8

Human IgE (myeloma, lambda), purified (isotype control)

20007-3L-100 100 ug
EUR 489.6

Human IgE (myeloma, lambda), purified (isotype control)

20007-3L-1000 1000 ug
EUR 3567.6

OPRA03556-1MG - IgG2b Kappa (kappa) myeloma protein

OPRA03556-1MG 1mg
EUR 249

OPRA03558-1MG - IgG2a Kappa (kappa) myeloma protein

OPRA03558-1MG 1mg
EUR 249

OPRA03562-1MG - IgM Lambda (lambda) myeloma protein

OPRA03562-1MG 1mg
EUR 249

Multiple Myeloma Derived Cell Line (NCU-MM-1)

T8055 1x10^6 cells / 1.0 ml Ask for price

Human Myeloma Immunoglobulin E (IgE) lambda Protein

abx061596-1ml 1 ml
EUR 526.8

Human IgM-FITC conjugate (myeloma, isotype control)

20007-2-MF 100 ug
EUR 196.8

OPRA03564-1MG - IgG3 Lambda (lambda) myeloma protein

OPRA03564-1MG 1mg
EUR 249

OPRA03566-1MG - IgG1 Lambda (lambda) myeloma protein

OPRA03566-1MG 1mg
EUR 249

OPRA03552-1MG - IgG2a Lambda (lambda) myeloma protein

OPRA03552-1MG 1mg
EUR 249

OPRA03555-1MG - IgG2b Lambda (lambda) myeloma protein

OPRA03555-1MG 1mg
EUR 249

Human Multiple Myeloma PB Plasma (Relapsed/Refractory)

ABC-TC3953 1 vial Ask for price
Description: Multiple Myeloma-PB-Plasma is obtained by centrifugation of Multiple Myeloma peripheral blood. Plasma has a diminished number of cells. Multiple Myeloma-PB-Plasma is available in both the newly diagnosed and relapsed/refractory stages.

Human IgM-Biotin conjugate (myeloma, isotype control)

20007-2-MB 100 ug
EUR 196.8

Goat Anti-Human IgM, Myeloma, Affinity Purified (Bulk)

10217-GAF-BLK 1g; bulk Ask for price

Hormone-Sensitive Multiple Myeloma Cell Line (MM.1S)

T8031 1x10^6 cells / 1.0 ml Ask for price

Hormone-Resistant Multiple Myeloma Cell Line (MM.1R)

T8032 1x10^6 cells / 1.0 ml Ask for price

Human IgM-Rhodamine conjugate (myeloma, isotype control)

20007-2-MR 100 ug
EUR 196.8

Human IgM (myeloma, >96%, non-immune, control; bulk size)

20007-2-B-100 100 mg Ask for price

Human IgM (myeloma, >96%, non-immune, control; bulk size)

20007-2-B-1000 1000 mg Ask for price

Human Myeloma- overexpressed gene protein, MYEOV ELISA KIT

ELI-36862h 96 Tests
EUR 988.8

HighQC™ Human Multiple Myeloma (MM) Cancer Stem Cell

ABC-SC0079 1 vial Ask for price
Description: Human Multiple Myeloma (MM) Cancer Stem Cell; Frozen Vial and Plated cells are available. Cells are only guaranteed with purchase of Gentaur Media and Gentaur Extra Cellular Matrix for appropriate cell culture, for 30 days from the date of shipment.

OPRA03545-1MG - Human IgM (myeloma) Fc5u fragment Protein

OPRA03545-1MG 1mg
EUR 319

Human Myeloma-overexpressed gene protein (MYEOV) ELISA Kit

RK11619 96T
EUR 280

Human Multiple Myeloma PB Plasma (Newly Diagnosed/Untreated)

ABC-TC3952 1 vial Ask for price
Description: Multiple Myeloma-PB-Plasma is obtained by centrifugation of Multiple Myeloma peripheral blood. Plasma has a diminished number of cells. Multiple Myeloma-PB-Plasma is available in both the newly diagnosed and relapsed/refractory stages.

Paraffin Tissue Section - Human Bone Tumor: Myeloma, Plasmacytic

T2235023-7 5 slides
EUR 262

Human Myeloma- overexpressed gene 2 protein, MYEOV2 ELISA KIT

ELI-46022h 96 Tests
EUR 988.8

Human IgM Fab mu fragment (myeloma), purified (isotype control)

20007-4 1 mg
EUR 270

Human Multiple Myeloma Bone Marrow Plasma (Relapsed/Refractory)

ABC-TC3949 1 vial Ask for price
Description: Multiple Myeloma-Bone Marrow Plasma is obtained by centrifuging the Multiple Myeloma-bone marrow. The plasma has a diminished number of cells and platelets. Multiple Myeloma-Bone Marrow plasma is available in both the newly diagnosed and relapsed/refractory stages.

MYEOV (untagged)-Human myeloma overexpressed (in a subset of t(11,14) positive multiple myelomas) (MYEOV)

SC123148 10 µg Ask for price

Multiple Myeloma Tumor-Associated Protein 2 (MMTAG2) Antibody

20-abx133575
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 30 ul

Multiple Myeloma Tumor-Associated Protein 2 (MMTAG2) Antibody

20-abx013775
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg

Multiple Myeloma Tumor-Associated Protein 2 (MMTAG2) Antibody

abx013775-100l 100 µl
EUR 43.75

Myeov2 (untagged ORF) - Rat myeloma overexpressed 2 (Myeov2), (10 ug)

RN200769 10 µg Ask for price

MYEOV (GFP-tagged) - Human myeloma overexpressed (in a subset of t(11;14) positive multiple myelomas) (MYEOV)

RG204125 10 µg Ask for price

Human IgM Fab mu fragment (myeloma)-HRP conjugate (isotype control)

20007-4-HP 100 ug
EUR 270

Myeloma tissue array with bone marrow tissue, 6 cases/24 cores

IBM291d row: 3; column: 8; cores: 24; cases: 6
EUR 42
Description: Myeloma tissue microarray, containing 4 cases myeloma and 2 bone marrow tissue, quadruple cores per case

Human Multiple Myeloma Bone Marrow Plasma (Newly Diagnosed/Untreated)

ABC-TC3948 1 vial Ask for price
Description: Multiple Myeloma-Bone Marrow Plasma is obtained by centrifuging the Multiple Myeloma-bone marrow. The plasma has a diminished number of cells and platelets. Multiple Myeloma-Bone Marrow plasma is available in both the newly diagnosed and relapsed/refractory stages.

MYEOV (untagged) - Human myeloma overexpressed (MYEOV), transcript variant 3

SC334867 10 µg Ask for price

MYEOV (untagged) - Human myeloma overexpressed (MYEOV), transcript variant 4

SC334868 10 µg Ask for price

MYEOV (untagged) - Human myeloma overexpressed (MYEOV), transcript variant 5

SC334869 10 µg Ask for price

MYEOV (untagged) - Human myeloma overexpressed (MYEOV), transcript variant 6

SC334870 10 µg Ask for price

MYEOV (untagged) - Human myeloma overexpressed (MYEOV), transcript variant 1

SC335274 10 µg Ask for price

Human IgM Fab mu fragment (myeloma)-FITC conjugate (isotype control)

20007-4-F 100 ug
EUR 270

MYEOV (Myc-DDK-tagged)-Human myeloma overexpressed (in a subset of t(11,14) positive multiple myelomas) (MYEOV)

RC204125 10 µg Ask for price

Human Multiple Myeloma Bone Marrow Mononuclear Cells (Newly Diagnosed)

ABC-TC3945 1 vial Ask for price
Description: Multiple Myeloma-Bone Marrow-Mononuclear Cells are isolated by diluting Multiple Myeloma-bone marrow with phosphate-buffered saline and using gradient separation. Multiple Myeloma Bone Marrow-Mononuclear Cells products are available in both the newly diagnosed and relapsed/refractory stages.

Human IgM Fab mu fragment (myeloma)-Biotin conjugate (isotype control)

20007-4-B 100 ug
EUR 270

Rat Multiple Myeloma Tumor-Associated Protein 2 (MMTAG2) ELISA Kit

abx533269-96tests 96 tests
EUR 687.5

Human IgM Fab mu fragment (myeloma)-Rhodamine conjugate (isotype control)

20007-4-R 100 ug
EUR 270

Human Multiple myeloma tumor-associated protein 2(C1orf35) ELISA kit

YLA0694HU-48T 48T Ask for price

Human Multiple myeloma tumor-associated protein 2(C1orf35) ELISA kit

YLA0694HU-96T 96T Ask for price

Human Multiple myeloma tumor-associated protein 2 (C1orf35) ELISA Kit

abx533267-96tests 96 tests
EUR 687.5

Mouse Myeloma-overexpressed gene 2 protein homolog (COPS9) ELISA Kit

abx534289-96tests 96 tests
EUR 687.5

Human Multiple Myeloma Bone Marrow Mononuclear Cells (Relapsed/Refractory)

ABC-TC3947 1 vial Ask for price
Description: Multiple Myeloma-Bone Marrow-Mononuclear Cells are isolated by diluting Multiple Myeloma-bone marrow with phosphate-buffered saline and using gradient separation. Multiple Myeloma Bone Marrow-Mononuclear Cells products are available in both the newly diagnosed and relapsed/refractory stages.

As an alternative, the lanthanide doped upconverting phosphor (UCP) has emerged as a new class of materials for use in optical imaging and sensing RET; they show photographs and high chemical stability and utilizing near infrared excitation. Approaches to sense the target analyte is given employing upconverting phosphors can be achieved by engineering the UCP to operate an analog to a fluorescent dye through Luminescence Resonance Energy Transfer (LRET) and the system as it is now at the center of optical sensing low concentration of important biological species and distance measurement.

Sean

Related Posts

Solid waste quantification and characterization in university of Nigeria, Nsukka campus, and recommendations for sustainable management

Solid waste quantification and characterization in university of Nigeria, Nsukka campus, and recommendations for sustainable management

Effectiveness of the mixture of nopal and cassava starch as clarifying substances in water purification: A case study in Colombia

Effectiveness of the mixture of nopal and cassava starch as clarifying substances in water purification: A case study in Colombia

Protein and Polysaccharide-Based Fiber Materials Generated from Ionic Liquids: A Review

Protein and Polysaccharide-Based Fiber Materials Generated from Ionic Liquids: A Review

Toward a Long-Term Artificial Lung

Toward a Long-Term Artificial Lung

No Comment

Leave a Reply

Your email address will not be published.

Recent Posts

March 2024
M T W T F S S
 123
45678910
11121314151617
18192021222324
25262728293031

Tags

Categories