Protein electrostatics: From computational and structural analysis to discovery of functional fingerprints and biotechnological design

Protein electrostatics: From computational and structural analysis to discovery of functional fingerprints and biotechnological design

Computing driven protein engineering aims to enable them to withstand an extended range of conditions and to mediate modified or novel functions. Therefore, it is very important for industrial biotechnology, biomedical and pay for new challenges in environmental science, such as biocatalysis for green chemistry and bioremediation.

To achieve this goal, it is important to clarify the molecular mechanisms underlying the stability of proteins and modulate their interactions. So far, much attention has been given to the packing of hydrophobic and polar interactions and the stability of the protein core.

Instead, the role of electrostatics and, in particular, surface interactions has received less attention. However, electrostatics plays an important role throughout the entire life cycle of proteins, because the initial folding steps to maturation, and is involved in the regulation of protein localization and interaction with cellular or other artificial molecule. Short and long-range electrostatic interactions, together with other forces, provide important guidance cues in the assembly of molecules and macromolecules.

We report here on a method for calculating electrostatic and for analysis of individual proteins or protein capable comparison sort by electrostatic similarity. Then, we give examples of electrostatic and fingerprint analysis in the evolution of the natural protein in the design and biotechnology, in areas as diverse as biocatalysis, antibodies and nanobody engineering, drug design and delivery, molecular virology, nanotechnology and regenerative medicine.
Biomimetic has emerged as a multi-disciplinary knowledge in several subjects biomedicine in recent decades, including biomaterials and dentistry.

In restorative dentistry, biomimetic approach has been applied to a variety of applications, such as restoring defective teeth using bioinspired peptides to achieve remineralization, bioactive and biomimetic biomaterials, and tissue engineering for regeneration. Advances in modern adhesive restorative materials, understanding the biomaterial-tissue interaction at the nano and micro further improved restorative material properties (such as color, morphology, and strength) to mimic natural teeth.

 Protein electrostatics: From computational and structural analysis to discovery of functional fingerprints and biotechnological design
Protein electrostatics: From computational and structural analysis to discovery of functional fingerprints and biotechnological design

Evaluating the spectral overlap with the cooling rate in UCP luminescence energy transfer system

The use of organic fluorophores based on well-established as a key tool in the biological sciences, with many biological-sensing method takes advantage of Forster Resonance Energy Transfer (FRET) between fluorescent organic dyes based on the following different one photon excitation.

However, work by absorbing UV-visible dyes as fluorescent tags and markers typically suffer from several drawbacks including relatively high energy excitation wavelengths, and autofluorescence competitive photobleaching, which often limit their effectiveness and longevity both in vitro and in vivo.

Human Myeloma IgM

GWB-9E845B 2 mg Ask for price

IgM, Kappa, Myeloma

MBS632924-1mg 1mg
EUR 735

IgM, Kappa, Myeloma

MBS632924-5x1mg 5x1mg
EUR 3165

Human Myeloma IgE

MBS318250-01mg 0.1mg
EUR 1090

Human Myeloma IgE

MBS318250-5x01mg 5x0.1mg
EUR 4735

IgG1, Kappa, Myeloma

MBS654726-1mg 1mg
EUR 765

IgG1, Kappa, Myeloma

MBS654726-5x1mg 5x1mg
EUR 3290

IgG1 LAMBDA MYELOMA

GWB-1F43F7 1 mg Ask for price

IgG1, Lambda, Myeloma

MBS655011-1mg 1mg
EUR 815

IgG1, Lambda, Myeloma

MBS655011-5x1mg 5x1mg
EUR 3515

IgG2a, Kappa, Myeloma

MBS655064-1mg 1mg
EUR 990

IgG2a, Kappa, Myeloma

MBS655064-5x1mg 5x1mg
EUR 4310

IgA, Kappa, Myeloma, Rat

MBS654734-1mg 1mg
EUR 1280

IgA, Kappa, Myeloma, Rat

MBS654734-5x1mg 5x1mg
EUR 5605

IgM, Human, Myeloma (HRP)

MBS655017-1mg 1mg
EUR 565

IgM, Human, Myeloma (HRP)

MBS655017-5x1mg 5x1mg
EUR 2380

IgE, Kappa, Myeloma, Rat

MBS655055-01mg 0.1mg
EUR 605

IgE, Kappa, Myeloma, Rat

MBS655055-5x01mg 5x0.1mg
EUR 2575

Human Myeloma IgM Fc5u

GWB-785456 1 mg Ask for price

IgM, Human, Myeloma (FITC)

MBS654926-1mg 1mg
EUR 535

IgM, Human, Myeloma (FITC)

MBS654926-5x1mg 5x1mg
EUR 2250

Human IgE Myeloma, Kappa

31-1010 100 ug
EUR 460
Description: Human IgE Myeloma, Kappa Protein

IgM, Human, Myeloma (TRITC)

MBS654794-1mg 1mg
EUR 535

IgM, Human, Myeloma (TRITC)

MBS654794-5x1mg 5x1mg
EUR 2250

IgA, Kappa, Myeloma, Mouse

MBS654850-1mg 1mg
EUR 735

IgA, Kappa, Myeloma, Mouse

MBS654850-5x1mg 5x1mg
EUR 3160

IgG2a, Kappa, Myeloma, Rat

MBS654878-1mg 1mg
EUR 790

IgG2a, Kappa, Myeloma, Rat

MBS654878-5x1mg 5x1mg
EUR 3395

RAT IgG1 LAMBDA MYELOMA

MBS230320-1mg 1mg
EUR 570

RAT IgG1 LAMBDA MYELOMA

MBS230320-5x1mg 5x1mg
EUR 2380

Human IgE Myeloma, Lambda

31R-AI032 200 ug
EUR 2500
Description: Purified Human IgE Myeloma, Lambda

Human Myeloma IgA2 kappa

GWB-50D1F7 1 mg Ask for price

Human Myeloma IgA1 kappa

GWB-81CAAB 5 mg Ask for price

IgM, Human, Myeloma (Biotin)

MBS654674-1mg 1mg
EUR 550

IgM, Human, Myeloma (Biotin)

MBS654674-5x1mg 5x1mg
EUR 2330

IgG2, Kappa, Human, Myeloma

MBS654820-1mg 1mg
EUR 525

IgG2, Kappa, Human, Myeloma

MBS654820-5x1mg 5x1mg
EUR 2205

IgD, Human Myeloma Plasma

MBS135570-01mg 0.1mg
EUR 505

IgD, Human Myeloma Plasma

MBS135570-05mg 0.5mg
EUR 1135

IgD, Human Myeloma Plasma

MBS135570-5x05mg 5x0.5mg
EUR 4845

IgM, Human Myeloma Plasma

MBS135578-10mg 10mg
EUR 780

IgM, Human Myeloma Plasma

MBS135578-5mg 5mg
EUR 505

IgM, Human Myeloma Plasma

MBS135578-5x10mg 5x10mg
EUR 3265

Human Myeloma IgA1 kappa

MBS318189-5mg 5mg
EUR 780

Human Myeloma IgA1 kappa

MBS318189-5x5mg 5x5mg
EUR 3260

Human Myeloma IgE Protein

abx061000-100ug 100 ug
EUR 1387.2

Human Myeloma IgM Protein

abx061005-5mg 5 mg
EUR 393.6

Human Myeloma IgM Protein

abx061006-2mg 2 mg
EUR 644.4

Human IgG1, Myeloma Plasma

20007-G1-1 1 mg
EUR 242.4

Human IgG2, Myeloma Plasma

20007-G2-1 1 mg
EUR 242.4

Human IgG3, Myeloma Plasma

20007-G3-1 1 mg
EUR 489.6

Human IgG4, Myeloma Plasma

20007-G4-500 500 ug
EUR 270

Human Myeloma IgA1 Lambda

GWB-2FBFF6 5 mg Ask for price

Human Myeloma IgE Protein

abx061000-100g 100 µg Ask for price

Human Myeloma IgE Protein

abx061000-10g 10 µg
EUR 1362.5

Human Myeloma IgE Protein

abx061000-50g 50 µg Ask for price

IgA1, Lambda, Myeloma, Human

MBS654905-1mg 1mg
EUR 370

IgA1, Lambda, Myeloma, Human

MBS654905-5mg 5mg
EUR 710

IgA1, Lambda, Myeloma, Human

MBS654905-5x5mg 5x5mg
EUR 3040

IgA1, Human Myeloma Plasma

MBS135562-10mg 10mg
EUR 960

IgA1, Human Myeloma Plasma

MBS135562-5mg 5mg
EUR 670

IgA1, Human Myeloma Plasma

MBS135562-5x10mg 5x10mg
EUR 4080

IgA2, Human Myeloma Plasma

MBS135565-10mg 10mg
EUR 850

IgA2, Human Myeloma Plasma

MBS135565-5mg 5mg
EUR 595

IgA2, Human Myeloma Plasma

MBS135565-5x10mg 5x10mg
EUR 3570

IgG1, Human Myeloma Plasma

MBS135566-10mg 10mg
EUR 920

IgG1, Human Myeloma Plasma

MBS135566-1mg 1mg
EUR 280

IgG1, Human Myeloma Plasma

MBS135566-5mg 5mg
EUR 840

IgG1, Human Myeloma Plasma

MBS135566-5x10mg 5x10mg
EUR 3910

Human Myeloma IgA1 Lambda

MBS318188-5mg 5mg
EUR 1070

Human Myeloma IgA1 Lambda

MBS318188-5x5mg 5x5mg
EUR 4630

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma)

MBS642341-02mL 0.2mL
EUR 695

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma)

MBS642341-5x02mL 5x0.2mL
EUR 2975

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (AP)

MBS6323253-02mL 0.2mL
EUR 980

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (AP)

MBS6323253-5x02mL 5x0.2mL
EUR 4250

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (APC)

MBS6323254-02mL 0.2mL
EUR 980

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (APC)

MBS6323254-5x02mL 5x0.2mL
EUR 4250

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (PE)

MBS6323263-02mL 0.2mL
EUR 980

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (PE)

MBS6323263-5x02mL 5x0.2mL
EUR 4250

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (FITC)

MBS6323256-02mL 0.2mL
EUR 980

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (FITC)

MBS6323256-5x02mL 5x0.2mL
EUR 4250

IgM, Human, Myeloma (Texas Red)

MBS654951-1mg 1mg
EUR 580

IgM, Human, Myeloma (Texas Red)

MBS654951-5x1mg 5x1mg
EUR 2460

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (Biotin)

MBS6323255-02mL 0.2mL
EUR 980

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (Biotin)

MBS6323255-5x02mL 5x0.2mL
EUR 4250

Leukemia - Multiple Myeloma Exosome

P141-MM - Ask for price

Myeloma Overexpressed (MYEOV) Antibody

20-abx113918
  • Ask for price
  • Ask for price
  • 150 ul
  • 50 ul

Myeloma Overexpressed (MYEOV) Antibody

abx235466-100ug 100 ug
EUR 661.2

Myeloma Overexpressed (MYEOV) Antibody

abx113918-100l 100 µl
EUR 612.5

Myeloma Overexpressed (MYEOV) Antibody

abx235466-100g 100 µg
EUR 350

Myeloma Overexpressed (MYEOV) Antibody

abx375599-96tests 96 tests
EUR 337.5

Human IgM Myeloma, purified (1mg)

AS10-1400 1 mg
EUR 179

HUMAN, IGM (MYELOMA), HRP, 1 MG

9403724 1MG
EUR 258.89

Human IgG1 Fab fragment (myeloma)

20007-G1-Fab 100 ug
EUR 270

Human IgA1 control, from Myeloma

MBS689753-1mg 1mg
EUR 265

Human IgA1 control, from Myeloma

MBS689753-5x1mg 5x1mg
EUR 1035

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (MaxLight 405)

MBS6323258-01mL 0.1mL
EUR 980

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (MaxLight 405)

MBS6323258-5x01mL 5x0.1mL
EUR 4250

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (MaxLight 490)

MBS6323259-01mL 0.1mL
EUR 980

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (MaxLight 490)

MBS6323259-5x01mL 5x0.1mL
EUR 4250

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (MaxLight 550)

MBS6323260-01mL 0.1mL
EUR 980

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (MaxLight 550)

MBS6323260-5x01mL 5x0.1mL
EUR 4250

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (MaxLight 650)

MBS6323261-01mL 0.1mL
EUR 980

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (MaxLight 650)

MBS6323261-5x01mL 5x0.1mL
EUR 4250

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (MaxLight 750)

MBS6323262-01mL 0.1mL
EUR 980

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (MaxLight 750)

MBS6323262-5x01mL 5x0.1mL
EUR 4250

Human Myeloma IgA2 kappa Protein

abx060999-1mg 1 mg
EUR 427.2

Human Myeloma IgE lambda Protein

abx061003-1mg 1 mg
EUR 4869.6

Human Myeloma IgG1 kappa Protein

abx061004-1mg 1 mg
EUR 460.8

Human IgE Myeloma Lambda protein

31C-CP4013 100 ug
EUR 338
Description: Purified Human IgE Lambda protein

IgM Fc5mu fragment, Human, Myeloma

MBS6120666-1mg 1(mg
EUR 730

IgM Fc5mu fragment, Human, Myeloma

MBS6120666-5x1mg 5x1mg
EUR 3065

IgM Fc5mu fragment, Human, Myeloma

MBS654670-1mg 1mg
EUR 730

IgM Fc5mu fragment, Human, Myeloma

MBS654670-5x1mg 5x1mg
EUR 3130

HUMAN, IGM (MYELOMA), FITC, 1 MG

9403723 1MG
EUR 288.17

Mouse Myeloma IgM k (TEPC 183)

GWB-32CF00 1 mg Ask for price

Human Myeloma IgA1 lambda Protein

abx060998-5mg 5 mg
EUR 644.4

Immunoglobulin A2 (IgA2) Myeloma 95%

GWB-8EBF9E 1 mg Ask for price

Immunoglobulin A1 (IgA1) Myeloma 95%

GWB-A82DC0 1 mg Ask for price

Human Myeloma IgA1 lambda Protein

abx060998-100g 100 µg Ask for price

Human Myeloma IgA1 lambda Protein

abx060998-10g 10 µg
EUR 1325

Human Myeloma IgA1 lambda Protein

abx060998-50g 50 µg Ask for price

Mouse Myeloma IgG1 k (MOPC 21)

GWB-8F354F 1 mg Ask for price

HUMAN, IGM (MYELOMA), BIOTIN, 1 MG

9403722 1MG
EUR 185.69

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (Azide free) (HRP)

MBS6323257-02mL 0.2mL
EUR 980

MYEOV, ID (MYEOV, OCIM, Myeloma-overexpressed gene protein, Oncogene in multiple myeloma) (Azide free) (HRP)

MBS6323257-5x02mL 5x0.2mL
EUR 4250

Leukemia - Multiple Myeloma Exosome RNA

P241-MM - Ask for price

Myeloma Overexpressed 2 (MYEOV2) Antibody

abx235467-100ug 100 ug
EUR 661.2

Myeloma Overexpressed 2 (MYEOV2) Antibody

abx235467-100g 100 µg
EUR 350

HUMAN, IGM (MYELOMA), UNCONJUGATED, 2 MG

9403720 1MG
EUR 244.25

Myeloma and bone marrow tissue array

T291e each
EUR 78
Description: Myeloma and bone marrow tissue array, 6 cases/ 24 cores (core size 1.5mm), replacing T291d

IgM Fc5mu fragment, Human, Myeloma (HRP)

MBS654860-1mg 1mg
EUR 985

IgM Fc5mu fragment, Human, Myeloma (HRP)

MBS654860-5x1mg 5x1mg
EUR 4290

As an alternative, the lanthanide doped upconverting phosphor (UCP) has emerged as a new class of materials for use in optical imaging and sensing RET; they show photographs and high chemical stability and utilizing near infrared excitation. Approaches to sense the target analyte is given employing upconverting phosphors can be achieved by engineering the UCP to operate an analog to a fluorescent dye through Luminescence Resonance Energy Transfer (LRET) and the system as it is now at the center of optical sensing low concentration of important biological species and distance measurement.

Sean

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